Source decomposition of the frontocentral auditory steady?state gamma band response in schizophrenia patients and healthy subjects

Aim Gamma-band auditory steady-state response (ASSR) is a neurophysiologic index that increasingly used as translational biomarker in the development of treatments neuropsychiatric disorders. While gamma-band ASSR generated by distributed networks highly interactive temporal and frontal cortical sources, majority human studies using electroencephalography (EEG) highlight activity from only single frontocentral scalp site, Fz, where responses tend to be largest reductions schizophrenia patients are most evident. However, no previous study has characterized relative source contributions which necessary step improve concordance preclinical clinical EEG studies. Methods A novel method back-project independent components was applied assess sources their proportional Fz well source-resolved 432 294 healthy subjects. Results Independent were detected orbitofrontal, bilateral superior/middle/inferior temporal, middle frontal, posterior cingulate gyri both groups. In contrast expectations, groups showed comparable contribution weight at Fz. present consistent with studies, group differences individual source-level detected. Conclusion Small multiple summate produce scalp-level The identification sensor represents promising methodology for measuring dissociable homologous targets future